Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ccnb1tm1Thnt
Name:	cyclin B1; targeted mutation 1, Tim Hunt
MGI ID:	MGI:2429976
Gene:	Ccnb1  Location: Chr13:100915247-100922994 bp, - strand  Genetic Position: Chr13, 53.23 cM
Alliance:	Ccnb1tm1Thnt page

Germline Transmission:	Earliest citation of germline transmission: J:47430
Parent Cell Line:	GK129 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence extending from within exon 5 into exon 9 was replaced by a Beta-geo cassette inserted by homologous recombination. The deleted region included the cyclin box which is involved in the binding of cell cycle division 2. (J:47430)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ccnb1 Mutation:	33 strains or lines available

Original:	J:47430 Brandeis M, et al., Cyclin B2-null mice develop normally and are fertile whereas cyclin B1-null mice die in utero. Proc Natl Acad Sci U S A. 1998 Apr 14;95(8):4344-9
All:	4 reference(s)