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Targeted Allele Detail
Symbol: Pou3f2tm1Tno
Name: POU domain, class 3, transcription factor 2; targeted mutation 1, Tetsuo Noda
MGI ID: MGI:2429695
Synonyms: Brn-2DeltaC
Gene: Pou3f2  Location: Chr4:22482780-22488366 bp, - strand  Genetic Position: Chr4, 9.73 cM
Germline Transmission:  Earliest citation of germline transmission: J:30429
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA 3' portion of the endogenous gene encoding both the POU specific and POU homeo domains was replaced by a PGK-neo cassette inserted by homologous recombination. The loss of octamer binding activity in homozygous mutant mice was demonstrated with electrophoresis mobility shift assays. (J:30429)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pou3f2 Mutation:  3 strains or lines available
Original:  J:30429 Nakai S, et al., The POU domain transcription factor Brn-2 is required for the determination of specific neuronal lineages in the hypothalamus of the mouse. Genes Dev. 1995 Dec 15;9(24):3109-21
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory