Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Igktm1Dhu
Name:	immunoglobulin kappa chain complex; targeted mutation 1, Dennis Huszar
MGI ID:	MGI:2429510
Synonyms:	Ckappa-, JH-, kappa-
Gene:	Igk  Location: Chr6:67532620-70703738 bp, + strand  Genetic Position: Chr6, 30.89 cM, cytoband F1-pter

Germline Transmission:	Earliest citation of germline transmission: J:4128
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutations:    Insertion, Intergenic deletion   Mutation details: A neomycin resistance gene cassette replaced sequence encompassing all 5 segments of the Igk-J region, the Igk intronic enhancer (Ekappa or Rr158), and Igk-C. (J:4128)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Igk Mutation:	25 strains or lines available

Original:	J:4128 Chen J, et al., B cell development in mice that lack one or both immunoglobulin kappa light chain genes. EMBO J. 1993 Mar;12(3):821-30
All:	52 reference(s)