Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Zap70tm2.1Mmal
Name:	zeta-chain (TCR) associated protein kinase; targeted mutation 2.1, Marie Malissen
MGI ID:	MGI:2388918
Synonyms:	ZAP-70 Y315F
Gene:	Zap70  Location: Chr1:36800879-36821899 bp, + strand  Genetic Position: Chr1, 15.41 cM, cytoband A4-C1
Alliance:	Zap70tm2.1Mmal page

Germline Transmission:	Earliest citation of germline transmission: J:71099
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: An intronic floxed neo cassette was removed by crossing to a cre-expressing deleter strain, leaving behind a tyrosine to phenylalanine knock-in mutation at position 315 (Y315F). Expression of the mutant allele was confirmed by sequence analysis of RT-PCR products from thymus of mutant animals. (J:71099)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Zap70 Mutation:	55 strains or lines available

Original:	J:71099 Magnan A, et al., T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. J Exp Med. 2001 Aug 20;194(4):491-505
All:	1 reference(s)