Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nfatc4tm1Jmk
Name:	nuclear factor of activated T cells, cytoplasmic, calcineurin dependent 4; targeted mutation 1, Jeffery D Molkentin
MGI ID:	MGI:2388915
Gene:	Nfatc4  Location: Chr14:56062252-56071400 bp, + strand  Genetic Position: Chr14, 28.19 cM, cytoband C1
Alliance:	Nfatc4tm1Jmk page

Germline Transmission:	Earliest citation of germline transmission: J:79608
Parent Cell Line:	AB2.2 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 3 through 5 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the Rel homology domain. Neither transcript nor protein was detected in cardiac tissue obtained from homozygous mutant mice. (J:79608)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nfatc4 Mutation:	36 strains or lines available

Original:	J:79608 Wilkins BJ, et al., Targeted Disruption of NFATc3, but Not NFATc4, Reveals an Intrinsic Defect in Calcineurin-Mediated Cardiac Hypertrophic Growth. Mol Cell Biol. 2002 Nov;22(21):7603-13
All:	5 reference(s)