Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Afptm2Ibmm
Name:	alpha fetoprotein; targeted mutation 2, Claude Szpirer
MGI ID:	MGI:2388723
Gene:	Afp  Location: Chr5:90638596-90656766 bp, + strand  Genetic Position: Chr5, 44.77 cM
Alliance:	Afptm2Ibmm page

Germline Transmission:	Earliest citation of germline transmission: J:79500
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A portion of exon 2 and all of exon 3 were replaced by a cassette containing lacZ and floxed neo. Beta-galactosidase expression was putatively driven by both promoters, which were left intact by the insertion. (J:79500)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Afp Mutation:	32 strains or lines available

Original:	J:79500 Gabant P, et al., Alpha-fetoprotein, the major fetal serum protein, is not essential for embryonic development but is required for female fertility. Proc Natl Acad Sci U S A. 2002 Oct 1;99(20):12865-70
All:	4 reference(s)