Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Esr1tm1Lja
Name:	estrogen receptor 1 (alpha); targeted mutation 1, J Larry Jameson
MGI ID:	MGI:2388611
Gene:	Esr1  Location: Chr10:4561989-4955633 bp, + strand  Genetic Position: Chr10, 2.03 cM
Alliance:	Esr1tm1Lja page

Germline Transmission:	Earliest citation of germline transmission: J:79228
Parent Cell Line:	HM-1 (ES Cell)
Strain of Origin:	129P2/OlaHsd-Hprt1b-m3

Allele Type:    Targeted Mutations:    Insertion, Nucleotide substitutions   Mutation details: Missense mutations at codons 207 and 208 were introduced at the endogenous locus via homologous recombination. The mutations were designed to substitute a glutamate (207) and glycine (208) with alanine residues. A floxed neo cassette was integrated upstream in intron 2 for selection. Mice carrying this allele were used to generate Esr1tm1.1Lja. (J:79228)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esr1 Mutation:	67 strains or lines available

Original:	J:79228 Jakacka M, et al., An Estrogen Receptor (ER)alpha Deoxyribonucleic Acid-Binding Domain Knock-In Mutation Provides Evidence for Nonclassical ER Pathway Signaling in Vivo. Mol Endocrinol. 2002 Oct;16(10):2188-201
All:	2 reference(s)