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Creb1em1Rst
Endonuclease-mediated Allele Detail
Summary
Symbol: Creb1em1Rst
Name: cAMP responsive element binding protein 1; endonuclease-mediated mutation 1, Randal S Tibbetts
MGI ID: MGI:6783446
Synonyms: CrebE153D
Gene: Creb1  Location: Chr1:64571963-64643707 bp, + strand  Genetic Position: Chr1, 32.74 cM, cytoband C1/C5
Alliance: Creb1em1Rst page
Mutation
origin
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Endonuclease-mediated (Not Specified)
Mutation:    Single point mutation
 
Mutation detailsGlutamic acid codon 153 (GAA) was targeted for change to an aspartic acid codon (GAC)(p.E153D) with an sgRNA (targeting GACTTTTCTTCTTCAATCCTTGG) and an ssODN template using CRISPR/Cas9 technology. This mutation disrupts the BS2 binding site that normally allows binding of protein phosphatase 2A through the PP2A B56 regulatory subunits. (J:307293)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Creb1 Mutation:  59 strains or lines available
References
Original:  J:307293 Kim SH, et al., Roles of constitutive and signal-dependent protein phosphatase 2A docking motifs in burst-attenuation of the cyclic AMP response element binding protein. J Biol Chem. 2021 Jun 22;:100908
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory