Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nr4a3em2Juz
Name:	nuclear receptor subfamily 4, group A, member 3; endonuclease-mediated mutation 2, Julie Zikherman
MGI ID:	MGI:6717380
Gene:	Nr4a3  Location: Chr4:48045153-48086447 bp, + strand  Genetic Position: Chr4, 26.07 cM, cytoband B2
Alliance:	Nr4a3em2Juz page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Null/knockout) Mutation:    Intragenic deletion   Mutation details: Exon 3, which contains the ATG start codon, was targeted with gRNA using CRISPR/Cas9 technology in zygotes containing the Nr4a1tm1Pcn allele, resulting in a 112 bp deletion. This allele represents founder line 3. (J:306652)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr4a3 Mutation:	53 strains or lines available

Original:	J:306652 Tan C, et al., NR4A nuclear receptors restrain B cell responses to antigen when second signals are absent or limiting. Nat Immunol. 2020 Oct;21(10):1267-1279
All:	1 reference(s)