Hsd17b3tm1.1Mpo
Targeted Allele Detail
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Symbol: |
Hsd17b3tm1.1Mpo |
Name: |
hydroxysteroid (17-beta) dehydrogenase 3; targeted mutation 1.1, Matti Poutanen |
MGI ID: |
MGI:6508688 |
Synonyms: |
Hsd17b3fl |
Gene: |
Hsd17b3 Location: Chr13:64206080-64237044 bp, - strand Genetic Position: Chr13, 33.26 cM, cytoband B3
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Alliance: |
Hsd17b3tm1.1Mpo page
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
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Mutation details: Using EUCOMM targeting vector HTGR04002_Z_5_C06, the locus was targeted for conditional knockout. The vector inserts an FRT site flanked lacZ/neomycin resistance fusion gene cassette and a loxP site into intron 2 (chr13: 64223896 on build GRCm39) and a second loxP site into intron 3 (chr13: 64224681). The lacZ/neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed.
(J:301756)
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Hsd17b3 Mutation: |
33 strains or lines available
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Original: |
J:301756 Sipila P, et al., The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. FASEB J. 2020 May;34(5):6111-6128 |
All: |
1 reference(s) |
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