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Hsd17b3tm1.1Mpo
Targeted Allele Detail
Summary
Symbol: Hsd17b3tm1.1Mpo
Name: hydroxysteroid (17-beta) dehydrogenase 3; targeted mutation 1.1, Matti Poutanen
MGI ID: MGI:6508688
Synonyms: Hsd17b3fl
Gene: Hsd17b3  Location: Chr13:64206080-64237044 bp, - strand  Genetic Position: Chr13, 33.26 cM, cytoband B3
Alliance: Hsd17b3tm1.1Mpo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:301756
Parent Cell Line:  G4 (ES Cell)
Strain of Origin:  (129S6/SvEvTac x C57BL/6NCrl)F1
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsUsing EUCOMM targeting vector HTGR04002_Z_5_C06, the locus was targeted for conditional knockout. The vector inserts an FRT site flanked lacZ/neomycin resistance fusion gene cassette and a loxP site into intron 2 (chr13: 64223896 on build GRCm39) and a second loxP site into intron 3 (chr13: 64224681). The lacZ/neo cassette was removed through subsequent flp-mediated recombination, leaving a conditional-ready allele with exon 3 floxed. (J:301756)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsd17b3 Mutation:  33 strains or lines available
References
Original:  J:301756 Sipila P, et al., The lack of HSD17B3 in male mice results in disturbed Leydig cell maturation and endocrine imbalance akin to humans with HSD17B3 deficiency. FASEB J. 2020 May;34(5):6111-6128
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory