Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nr1i2em1Neg
Name:	nuclear receptor subfamily 1, group I, member 2; endonuclease-mediated mutation 1, Masahiko Negishi
MGI ID:	MGI:6507720
Synonyms:	PXR S347A
Gene:	Nr1i2  Location: Chr16:38068711-38115211 bp, - strand  Genetic Position: Chr16, 26.64 cM
Alliance:	Nr1i2em1Neg page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Not Applicable) Mutations:    Insertion, Nucleotide substitutions     An S347A (TCC to GCT) mutation is introduced to exon 7 via CRISPR/Cas9 methodologies. (J:302068)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr1i2 Mutation:	33 strains or lines available

Original:	J:302068 Hu H, et al., PXR phosphorylated at Ser350 transduces a glucose signal to repress the estrogen sulfotransferase gene in human liver cells and fasting signal in mouse livers. Biochem Pharmacol. 2020 Oct;180:114197
All:	2 reference(s)