Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Pax3tm1(FOXO1A)Gcg
Name:	paired box 3; targeted mutation 1, Gerard C Grosveld
MGI ID:	MGI:2388378
Synonyms:	Pax3-FKHR
Gene:	Pax3  Location: Chr1:78077904-78173771 bp, - strand  Genetic Position: Chr1, 39.79 cM
Alliance:	Pax3tm1(FOXO1A)Gcg page

Germline Transmission:	Earliest citation of germline transmission: J:79365
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Inserted expressed sequence) Mutations:    Insertion, Intragenic deletion   Pax3tm1(FOXO1A)Gcg expresses 1 gene Knock-in expresses: Organism Expressed Gene Homolog in Mouse Note human FOXO1 (2308) Foxo1  (MGI:1890077) The 3' half of FOXO1 is fused to mouse Pax3   Mutation details: To replicate t(2;13), a chromosomal transloction associated with the pediatric disease alveolar rhabdomyosarcoma, a sequence fragment from a PAX3-FOXO1A fusion cDNA was inserted at the endogenous locus via homologous recombination. The last 50 bp of the endogenous exon 7 were replaced with related PAX3 sequence and a 3' portion of FOXO1A. Various analyses indicated low levels of expression of the knock-in allele. (J:79365)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pax3 Mutation:	50 strains or lines available

Original:	J:79365 Lagutina I, et al., Pax3-FKHR knock-in mice show developmental aberrations but do not develop tumors. Mol Cell Biol. 2002 Oct;22(20):7204-16
All:	1 reference(s)