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Cd44tm1.1Mka
Targeted Allele Detail
Summary
Symbol: Cd44tm1.1Mka
Name: CD44 antigen; targeted mutation 1.1, Michael Karin
MGI ID: MGI:6468303
Synonyms: Cd44F
Gene: Cd44  Location: Chr2:102641486-102732010 bp, - strand  Genetic Position: Chr2, 54.13 cM
Alliance: Cd44tm1.1Mka page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:262540
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129S/SvEv
Mutation
description
Allele Type:    Targeted (Conditional ready)
Mutation:    Insertion
 
Mutation detailsExon 3 was flanked with loxP sites. An frt-flanked neomycin selection cassette was removed in ES cells prior to the creation of chimeric mice. (J:262540)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd44 Mutation:  67 strains or lines available
References
Original:  J:262540 Dhar D, et al., Liver Cancer Initiation Requires p53 Inhibition by CD44-Enhanced Growth Factor Signaling. Cancer Cell. 2018 Jun 11;33(6):1061-1077.e6
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory