Hnf1a<tm1.1Jfer> Targeted Allele Detail MGI Mouse (MGI:6434289)

About Help FAQ

Hnf1a^tm1.1Jfer
Targeted Allele Detail

Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Summary

Symbol:	Hnf1a^tm1.1Jfer
Name:	HNF1 homeobox A; targeted mutation 1.1, Jorge Ferrer
MGI ID:	MGI:6434289
Synonyms:	Hnf1a^LoxP
Gene:	Hnf1a Location: Chr5:115087039-115109121 bp, - strand Genetic Position: Chr5, 55.99 cM, cytoband F
Alliance:	Hnf1a^tm1.1Jfer page

Mutation
origin

Germline Transmission:	Earliest citation of germline transmission: J:288604
Parent Cell Line:	JM8.F6 (ES Cell)
Strain of Origin:	C57BL/6N

Mutation
description

Allele Type:		Targeted (Conditional ready)
Mutation:		Insertion
		Exon 2 was floxed. Flp-mediated recombination removed the selection cassette. (J:288604)

Expression

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Find Mice (IMSR)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available Cell Lines: 0 lines available
Carrying any Hnf1a Mutation:	29 strains or lines available

References

Original:	J:288604 Kalisz M, et al., HNF1A recruits KDM6A to activate differentiated acinar cell programs that suppress pancreatic cancer. EMBO J. 2020 May 4;39(9):e102808
All:	1 reference(s)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/16/2024 MGI 6.23