Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Irf5tm1.1Mrl
Name:	interferon regulatory factor 5; targeted mutation 1.1, Merck Research Laboratory
MGI ID:	MGI:6433825
Gene:	Irf5  Location: Chr6:29526624-29541870 bp, + strand  Genetic Position: Chr6, 12.36 cM
Alliance:	Irf5tm1.1Mrl page

Germline Transmission:	Earliest citation of germline transmission: J:147112
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 3 to 9 were flanked by loxP sites (size of loxP-flanked region 4.2 kb). A polyadenylation signal (hGHpA: human Growth Hormone polyadenylation signal) has been inserted 3' of the gene in order to prevent downstream transcription. The conditional KO allele was obtained after Flp-mediated removal of the selection marker. (J:147112)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf5 Mutation:	28 strains or lines available

Original:	J:147112 Taconic, Information obtained from Taconic website. MGI Direct Data Submission. 2006-2017;
All:	1 reference(s)