Summary | Mutation origin | Mutation description | Recombinase activity | Phenotypes | Find Mice (IMSR) | References

Symbol:	Aldh1a1tm1.1(cre/ERT2)Cai
Name:	aldehyde dehydrogenase family 1, subfamily A1; targeted mutation 1.1, Huaibin Cai
MGI ID:	MGI:6423547
Synonyms:	Aldh1a1P2A-CreERT2
Gene:	Aldh1a1  Location: Chr19:20470079-20620829 bp, + strand  Genetic Position: Chr19, 13.91 cM
Alliance:	Aldh1a1tm1.1(cre/ERT2)Cai page

Germline Transmission:	Earliest citation of germline transmission: J:280705
Parent Cell Line:	JM8A3 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Aldh1a1tm1.1(cre/ERT2)Cai expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aldh1a1 (MGI:1353450)   Mutation details: The targeting construct "pDNDF-7-DTA-5 arm-P2A-CreERT2-STOP-Frt-Neo-Frt-3 arm-DTA" replaced the stop codon. Flp-mediated recombination removed the selection cassette. (J:280705)

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1a1 (mouse) Summary of all recombinase alleles driven by Aldh1a1. Comparative matrix view of recombinase activities Alliance mouse Aldh1a1 gene page

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1a1 Mutation:	37 strains or lines available

Original:	J:280705 Wu J, et al., Distinct Connectivity and Functionality of Aldehyde Dehydrogenase 1a1-Positive Nigrostriatal Dopaminergic Neurons in Motor Learning. Cell Rep. 2019 Jul 30;28(5):1167-1181.e7
All:	1 reference(s)