Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ace2em2Shyy
Name:	angiotensin converting enzyme 2; endonuclease-mediated mutation 2, John Y J Shyy
MGI ID:	MGI:6406965
Synonyms:	ACE2 S680D KI
Gene:	Ace2  Location: ChrX:162922338-162971414 bp, + strand  Genetic Position: ChrX, 76.12 cM, cytoband F5
Alliance:	Ace2em2Shyy page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Nucleotide substitutions   Mutation details: CRISPR-Cas9 genome editing technology was used to modify codon 680 TCC (coding Ser680) to GAC (coding Asp). (J:286356)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ace2 Mutation:	54 strains or lines available

Original:	J:286356 Zhang J, et al., AMP-activated Protein Kinase Phosphorylation of Angiotensin-Converting Enzyme 2 in Endothelium Mitigates Pulmonary Hypertension. Am J Respir Crit Care Med. 2018 Aug 15;198(4):509-520
All:	2 reference(s)