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Transgene Detail
Symbol: Tg(tetO-Twist1,-luc)1Dwf
Name: transgene insertion 1, Dean Felsher
MGI ID: MGI:6387223
Synonyms: Twist1-tetO7-luc
Transgene: Tg(tetO-Twist1,-luc)1Dwf  Location: unknown  
Strain of Origin:  FVB/N
Transgene Type:    Transgenic (Inducible, Inserted expressed sequence, Reporter)
Mutation:    Insertion
Tg(tetO-Twist1,-luc)1Dwf expresses 1 gene
Mutation detailsThe transgenic construct is designed with a bidirectional tetracycline responsive promoter containing the Tet-responsive element (TRE or tetO7 seven copies of the 42-bp tet operator sequence [tetO]) directing expression of the mouse Twist1 gene on one side and the luciferase (luc) gene on the other side. (J:185196)
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:185196 Tran PT, et al., Twist1 suppresses senescence programs and thereby accelerates and maintains mutant kras-induced lung tumorigenesis. PLoS Genet. 2012 May;8(5):e1002650
All:  6 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
The Jackson Laboratory