Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Aldh1b1tm1.1(cre/ERT2)Agav
Name:	aldehyde dehydrogenase 1 family, member B1; targeted mutation 1.1, Anthony Gavalas
MGI ID:	MGI:6382179
Synonyms:	Aldh1b1CreERT2, Aldh1b1tm2(CreERT2)Agav
Gene:	Aldh1b1  Location: Chr4:45799022-45804604 bp, + strand  Genetic Position: Chr4, 24.35 cM, cytoband B2
Alliance:	Aldh1b1tm1.1(cre/ERT2)Agav page

Germline Transmission:	Earliest citation of germline transmission: J:280398
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Inducible, Recombinase) Inducer:    tamoxifen Mutations:    Insertion, Intragenic deletion   Aldh1b1tm1.1(cre/ERT2)Agav expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Aldh1b1 (MGI:1919785)   Mutation details: The targeting construct consisting of the bicistronic Aldh1b1/P2A/CreERT2 transgene followed by the FRT-PGKneo- pA-FRT selection cassette was inserted in the endogenous Aldh1b1 locus to replace the coding region of mouse Aldh1b1 gene. The neo selection cassette was removed by Flp recombinase. (J:280398)

Activity:	Tissue activity of this recombinase allele
Driver:	Aldh1b1 (mouse) Summary of all recombinase alleles driven by Aldh1b1. Comparative matrix view of recombinase activities Alliance mouse Aldh1b1 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Aldh1b1 Mutation:	34 strains or lines available

Original:	J:280398 Mameishvili E, et al., Aldh1b1 expression defines progenitor cells in the adult pancreas and is required for Kras-induced pancreatic cancer. Proc Natl Acad Sci U S A. 2019 Oct 8;116(41):20679-20688
All:	1 reference(s)