Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol: Mat1atm1Jmm Name: methionine adenosyltransferase 1A; targeted mutation 1, Jose M Mato MGI ID: MGI:2388143 Gene: Mat1a  Location: Chr14:40826992-40846369 bp, + strand  Genetic Position: Chr14, 22.36 cM, cytoband C1 Alliance: Mat1atm1Jmm page

Liver histology from 8 month old Mat1atm1Jmm/Mat1atm1Jmm mice fed a normal diet Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:69408
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129/Sv

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 3 via homologous recombination. Absence of gene expression in homozygous mutant animals was verified by Northern and Western blot of liver RNA and proteins. (J:69408)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Mat1a Mutation:	18 strains or lines available

Original:	J:69408 Lu SC, et al., Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A. 2001 May 8;98(10):5560-5
All:	8 reference(s)