Summary | Mutation origin | Mutation description | Expression | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Wt1em1(cre/ERT2)Bzsh
Name:	WT1 transcription factor; endonuclease-mediated mutation 1, Bin Zhou
MGI ID:	MGI:6361467
Synonyms:	Wt1-CrexER
Gene:	Wt1  Location: Chr2:104956874-105003959 bp, + strand  Genetic Position: Chr2, 55.06 cM, cytoband E
Alliance:	Wt1em1(cre/ERT2)Bzsh page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Conditional ready, Inducible, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Wt1em1(cre/ERT2)Bzsh expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Wt1 (MGI:98968)   Mutation details: The mouse line was generated by homologous recombination using the CRISPR/Cas9 technology. A complementary DNA encoding Cre recombinase fused with 2 rox sequences flanking a mutant form of the ESR hormone-binding domain (ERT2) was inserted into the translational start site of the Wt1 gene and followed by a polyadenylation sequence. (J:278094)

Activity:	Tissue activity of this recombinase allele
Driver:	Wt1 (mouse) Summary of all recombinase alleles driven by Wt1. Comparative matrix view of recombinase activities Alliance mouse Wt1 gene page

In Mice Carrying this Mutation:

40 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Wt1 Mutation:	34 strains or lines available

Original:	J:278094 Pu W, et al., Genetic Targeting of Organ-Specific Blood Vessels. Circ Res. 2018 Jun 22;123(1):86-99
All:	1 reference(s)