Summary | Mutation origin | Mutation description | Recombinase activity | Find Mice (IMSR) | References

Symbol:	Atf3tm1.1(cre/ERT2)Msra
Name:	activating transcription factor 3; targeted mutation 1.1, Matt S Ramer
MGI ID:	MGI:6360893
Synonyms:	ATF3-CreERT2
Gene:	Atf3  Location: Chr1:190902493-190915530 bp, - strand  Genetic Position: Chr1, 96.28 cM, cytoband H6
Alliance:	Atf3tm1.1(cre/ERT2)Msra page

Germline Transmission:	Earliest citation of germline transmission: J:278945
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129S/SvEv

Allele Type:    Targeted (Inducible, Null/knockout, Recombinase) Inducer:    tamoxifen Mutation:    Insertion   Atf3tm1.1(cre/ERT2)Msra expression driven by 1 gene Knock-in expression driven by: Organism Driver Gene Note mouse Atf3 (MGI:109384)   Mutation details: Thetargeting vector was constructed to insert a construct directly after the ATG start codon of the mouse Atf3 gene containing: Cre fused to the mutated estrogen-ligand binding domain (CreERT2), 1.2 kb of Atf3 3' untranslated region, a Simian virus 40 stop signal and a neomycin cassette flanked by two FLP recognition target sites. The neo cassette was removed from founders by crossing with Flp recombinase mice. It is a null allele. (J:278945)

Activity:	Tissue activity of this recombinase allele
Driver:	Atf3 (mouse) Summary of all recombinase alleles driven by Atf3. Comparative matrix view of recombinase activities Alliance mouse Atf3 gene page

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atf3 Mutation:	19 strains or lines available

Original:	J:278945 Denk F, et al., Tamoxifen induces cellular stress in the nervous system by inhibiting cholesterol synthesis. Acta Neuropathol Commun. 2015 Nov 26;3:74
All:	2 reference(s)