Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1.2Jea
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.2, Freddy Jeanneteau
MGI ID:	MGI:6356400
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1.2Jea page

Germline Transmission:	Earliest citation of germline transmission: J:277414
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	C57BL/6

Allele Type:    Targeted (Not Applicable) Mutations:    Insertion, Nucleotide substitutions   Mutation details: A loxP_2272 site was inserted upstream of exon 2, and an FRT flanked neo cassette, a loxP site, an inverted mutated exon 2 with two serine to alanine mutations (S152A and S284A), a loxP_2272 site and a loxP site were inserted downstream of exon 2. Flp mediated recombination removed the neo cassette. Cre mediated recombination removed the wild-type exon 2 and flipped the mutant exon 2 into the correct orientation. This allele lacks the BDNF-dependent GR-phosphorylation sites in exon 2. (J:277414)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:277414 Arango-Lievano M, et al., Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors. Proc Natl Acad Sci U S A. 2019 Jun 25;116(26):13097-13106
All:	2 reference(s)