Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Rr102tm1.2Ics
Name:	regulatory region 102; targeted mutation 1.2, Mouse Clinical Institute
MGI ID:	MGI:6336135
Synonyms:	Egr2tm1.2Ics, Krox20deltaA
Gene:	Rr102  Location: unknown  Genetic Position: Chr10, Syntenic
Alliance:	Rr102tm1.2Ics page

Germline Transmission:	Earliest citation of germline transmission: J:277269
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Modified regulatory region) Mutations:    Insertion, Intragenic deletion   Mutation details: An FRT site flanked neomycin resistance cassette and a loxP site flanked chicken transcriptional enhancer element A that contains specific mutations in the Egr2 binding sites that prevent binding of wild-type Egr2 and instead allow binding of a mutant Egr2 protein, and an F3-flanked mouse element A replaced the wild-type Egr2 autoregulatory element A. Flp-mediated recombination removed the F3 flanked mouse element A and the neo cassette and cre-mediated recombination removed the floxed chicken element A. (J:277269)

In Mice Carrying this Mutation:

8 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rr102 Mutation:	0 strains or lines available

Original:	J:277269 Bouchoucha YX, et al., Dissection of a Krox20 positive feedback loop driving cell fate choices in hindbrain patterning. Mol Syst Biol. 2013;9:690
All:	2 reference(s)