Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Nfkb2m5Btlr
Name:	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 5, Bruce Beutler
MGI ID:	MGI:6305804
Synonyms:	humbert
Gene:	Nfkb2  Location: Chr19:46292759-46300824 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Alliance:	Nfkb2m5Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: G to A transition at base pair 46,307,441 (v38) on chromosome 19, or base pair 3,122 in the GenBank genomic regionNC_000085. The mutation corresponds to residue 782 in the mRNA sequence NM_019408 (variant 1) within exon 6 of 22 total exons. The mutation results in an arginine to histidine substitution at position 158 (R158H) in all isoforms of the NF-B2 protein. (J:274962) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:	49 strains or lines available

Original:	J:274962 Choi JH, et al., Mutagenetix entry for humbert. MGI Direct Data Submission. 2019;
All:	1 reference(s)