Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Nfkb2M4Btlr
Name:	nuclear factor of kappa light polypeptide gene enhancer in B cells 2, p49/p100; mutation 4, Bruce Beutler
MGI ID:	MGI:6305800
Synonyms:	Nabukov
Gene:	Nfkb2  Location: Chr19:46292759-46300824 bp, + strand  Genetic Position: Chr19, 38.8 cM, cytoband C3-D2
Alliance:	Nfkb2M4Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: A to G transition at base pair 46,308,439 (v38) on chromosome 19, or base pair 4,120 in the GenBank genomic regionNC_000085.The mutation corresponds to residue 1,256 in the mRNA sequence NM_019408 (variant 1) within exon 10 of 22 total exons. The mutation results in an aspartic acid to glycine substitution at position 316 (D316G) in all isoforms of the NF-B2 protein. (J:274961) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfkb2 Mutation:	49 strains or lines available

Original:	J:274961 Choi JH, et al., Mutagenetix entry for Nabukov. MGI Direct Data Submission. 2019;
All:	1 reference(s)