Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Irf8m2Btlr
Name:	interferon regulatory factor 8; mutation 2, Bruce Beutler
MGI ID:	MGI:6305310
Synonyms:	gemini2
Gene:	Irf8  Location: Chr8:121463097-121483433 bp, + strand  Genetic Position: Chr8, 70.05 cM
Alliance:	Irf8m2Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: ENU-induced T to C transition at base pair 120,753,707 (v38) on chromosome 8, or base pair 17,350 in the GenBank genomic region NC_000074 encoding Irf8. The mutation corresponds to residue 1,009 in the mRNA sequence NM_008320 within exon 7 of 9 total exons. The mutation results in substitution of valine for an alanine at position 319 (V319A) in the IRF8 protein. (J:274937) Inheritance:    Recessive

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf8 Mutation:	32 strains or lines available

Original:	J:274937 Zhong X, et al., Mutagenetix entry for gemini2. MGI Direct Data Submission. 2019;
All:	1 reference(s)