Tcf7em1Hhx
Endonuclease-mediated Allele Detail
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| Symbol: |
Tcf7em1Hhx |
| Name: |
transcription factor 7, T cell specific; endonuclease-mediated mutation 1, Hai-Hui Xue |
| MGI ID: |
MGI:6277162 |
| Synonyms: |
Tcf1deltaHMG |
| Gene: |
Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
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| Alliance: |
Tcf7em1Hhx page
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| Allele Type: |
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Endonuclease-mediated (Not Applicable) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: CRISPR/cas9 mediated recombination inserted a stop codon on exon 8 after the codon encoding Val304. This mutation truncates the high mobility group (HMG) domain at the C terminus interfering with the intrinsic histone deacetylase (HDAC) activity.
(J:247679)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Tcf7 Mutation: |
24 strains or lines available
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| Original: |
J:247679 Xu Z, et al., Cutting Edge: beta-Catenin-Interacting Tcf1 Isoforms Are Essential for Thymocyte Survival but Dispensable for Thymic Maturation Transitions. J Immunol. 2017 May 01;198(9):3404-3409 |
| All: |
3 reference(s) |
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Analysis Tools
