Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thraem3Ffla
Name:	thyroid hormone receptor alpha; endonuclease-mediated mutation 3, Frederic Flamant
MGI ID:	MGI:6272835
Synonyms:	Thra395fs485X, ThraL1
Gene:	Thra  Location: Chr11:98631539-98659832 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Alliance:	Thraem3Ffla page

Strain of Origin:

C57BL/6

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Not Specified   Mutation details: CRISPR-targeting of exon 9 produced a +2 frameshift mutation between codon 395 producing an amphigoric proteins with a 90 amino acid extension. (J:268664)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:	39 strains or lines available

Original:	J:268664 Markossian S, et al., CRISPR/Cas9 Editing of the Mouse Thra Gene Produces Models with Variable Resistance to Thyroid Hormone. Thyroid. 2018 Jan;28(1):139-150
All:	1 reference(s)