Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf1M3Btlr
Name:	interferon regulatory factor 1; mutation 3, Bruce Beutler
MGI ID:	MGI:6269378
Synonyms:	Longs_peak
Gene:	Irf1  Location: Chr11:53660841-53669200 bp, + strand  Genetic Position: Chr11, 32.0 cM
Alliance:	Irf1M3Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: ENU-induced T to A transversion at base pair 53,775,936 (v38) on chromosome 11, or base pair 5,923 in the GenBank genomic region NC_000077. The mutation corresponds to residue 1,008 in the mRNA sequence NM_008390 within exon 9 of 10 total exons. The mutation results in a tryptophan to arginine substitution at position 247 (W247R) in the IRF1 protein. (J:267677) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf1 Mutation:	19 strains or lines available

Original:	J:267677 Zhong X, et al., Mutagenetix entry for Longs_peak. MGI Direct Data Submission. 2018;
All:	1 reference(s)