Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Nr3c1tm1.1Himo
Name:	nuclear receptor subfamily 3, group C, member 1; targeted mutation 1.1, Hisashi Mori
MGI ID:	MGI:6201713
Synonyms:	Nr3c1loxP
Gene:	Nr3c1  Location: Chr18:39543598-39652474 bp, - strand  Genetic Position: Chr18, 21.09 cM
Alliance:	Nr3c1tm1.1Himo page

Germline Transmission:	Earliest citation of germline transmission: J:264153
Parent Cell Line:	RENKA (ES Cell)
Strain of Origin:	C57BL/6N

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Two loxP sites were inserted into mouse Nr3c1 gene to flank exon 3, follwed by a pgk-Neo cassette flanked by two FRT sites by homologous recombination in ES cells. The chimeric mouse obtained was crossed with a CAG-FLPe mouse to delete the pgk-neo cassette and establish the mouse line. (J:264153)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Nr3c1 Mutation:	34 strains or lines available

Original:	J:264153 Inoue R, et al., Glucocorticoid receptor-mediated amygdalar metaplasticity underlies adaptive modulation of fear memory by stress. Elife. 2018 Jun 26;7:e34135
All:	1 reference(s)