Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Tcf12em1Jlr
Name:	transcription factor 12; endonuclease-mediated mutation 1, John Rubenstein
MGI ID:	MGI:6200109
Synonyms:	hs623Tm1
Gene:	Tcf12  Location: Chr9:71751534-72019611 bp, - strand  Genetic Position: Chr9, 39.85 cM
Alliance:	Tcf12em1Jlr page

Strain of Origin:

CD-1

Allele Type:    Endonuclease-mediated (Not Specified) Mutation:    Intragenic deletion   Mutation details: CRISPR/Cas9 mediated recombination deleted a 734 bp region (mm9; chr9:71822812-71823548) of an enhancer element (named hs623) in an intron of the locus. RTqPCR analysis determined that expression of the short isoforms (3 and 4) is reduced in the medial ganglionic eminence of homozygous mice but, expression of the long isoforms (1 and 2) is not reduced. (J:264806)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf12 Mutation:	74 strains or lines available

Original:	J:264806 Sandberg M, et al., Genomic analysis of transcriptional networks directing progression of cell states during MGE development. Neural Dev. 2018 Sep 14;13(1):21
All:	1 reference(s)