Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Yap1em1Pwa
Name:	yes-associated protein 1; endonuclease-mediated mutation 1, Ping Wang
MGI ID:	MGI:6198003
Synonyms:	YapK327M
Gene:	Yap1  Location: Chr9:7932000-8004597 bp, - strand  Genetic Position: Chr9, 2.46 cM
Alliance:	Yap1em1Pwa page

Strain of Origin:

Not Specified

Allele Type:    Endonuclease-mediated (Not Applicable) Mutation:    Nucleotide substitutions     CRISPR/cas9 mediated recombination created an AAA to ATG mutation resulting in a K327M substitution. (J:264228)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Yap1 Mutation:	37 strains or lines available

Original:	J:264228 Fang L, et al., SET1A-Mediated Mono-Methylation at K342 Regulates YAP Activation by Blocking Its Nuclear Export and Promotes Tumorigenesis. Cancer Cell. 2018 Jul 9;34(1):103-118.e9
All:	1 reference(s)