Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tcf4em2Bdph
Name:	transcription factor 4; endonuclease-mediated mutation 2, Benjamin D Philpot
MGI ID:	MGI:6157964
Synonyms:	Tcf4delta574-579
Gene:	Tcf4  Location: Chr18:69476500-69821038 bp, + strand  Genetic Position: Chr18, 43.23 cM, cytoband E2
Alliance:	Tcf4em2Bdph page

Strain of Origin:

C57BL/6J

Allele Type:    Endonuclease-mediated (Dominant negative) Mutation:    Intragenic deletion     CRISPR/Cas9 technology generated an in-frame deletion of six amino acids (aa 574-579). (J:254983)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tcf4 Mutation:	56 strains or lines available

Original:	J:254983 Thaxton C, et al., Common Pathophysiology in Multiple Mouse Models of Pitt-Hopkins Syndrome. J Neurosci. 2018 Jan 24;38(4):918-936
All:	2 reference(s)