Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Bace1tm1.1Yanr
Name:	beta-site APP cleaving enzyme 1; targeted mutation 1.1, Riqiang Yan
MGI ID:	MGI:6150902
Synonyms:	BACE1fl
Gene:	Bace1  Location: Chr9:45749878-45775694 bp, + strand  Genetic Position: Chr9, 25.22 cM
Alliance:	Bace1tm1.1Yanr page

Germline Transmission:	Earliest citation of germline transmission: J:259749
Parent Cell Line:	C2 (Nagy) (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The allele was generated to insert loxP sites flanking exon 2 of the Bace1 gene. The neo cassette flanked with FLP recombinase target (FRT) sites was removed from founder mice by crossing with crossed with the FLP deleter strain. (J:259749)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Bace1 Mutation:	27 strains or lines available

Original:	J:259749 Hu X, et al., BACE1 deletion in the adult mouse reverses preformed amyloid deposition and improves cognitive functions. J Exp Med. 2018 Mar 5;215(3):927-940
All:	3 reference(s)