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Pdx1tm1.1(flpo)Most
Targeted Allele Detail
Nomenclature
Symbol: Pdx1tm1.1(flpo)Most
Name: pancreatic and duodenal homeobox 1; targeted mutation 1.1, Michael C Ostrowski
MGI ID: MGI:6119579
Synonyms: PdxFlpOki
Gene: Pdx1  Location: Chr5:147270131-147275149 bp, + strand  Genetic Position: Chr5, 86.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:248550
Parent Cell Line:  S1B6 (ES Cell)
Strain of Origin:  129S1/SvImJ or C57BL/6J
Mutation
description
Allele Type:    Targeted (Recombinase)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA Flpo fragment followed by LoxP-Neo-LoxP was inserted by homologous recombination at the start codon of the Pdx1 gene, replacing exon 1. The neo cassette was removed by crossing with cre expressing mice. (J:248550)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pdx1     Summary of all recombinase alleles driven by Pdx1. Comparative matrix view of recombinase activities
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Pdx1 Mutation:  22 strains or lines available
References
Original:  J:248550 Wu J, et al., Generation of a pancreatic cancer model using a Pdx1-Flp recombinase knock-in allele. PLoS One. 2017;12(9):e0184984
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory