Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Sox3em1(Sox2)Pqt
Name:	SRY (sex determining region Y)-box 3; endonuclease-mediated mutation 1, Paul Q Thomas
MGI ID:	MGI:6116390
Synonyms:	Sox3Sox2KI
Gene:	Sox3  Location: ChrX:59934972-59937036 bp, - strand  Genetic Position: ChrX, 33.66 cM, cytoband A7.3-B
Alliance:	Sox3em1(Sox2)Pqt page

Strain of Origin:

C57BL/6N

Allele Type:    Endonuclease-mediated (Inserted expressed sequence, Null/knockout) Mutations:    Insertion, Intragenic deletion   Sox3em1(Sox2)Pqt expresses 1 gene Knock-in expresses: Organism Expressed Gene Note Not Specified Sox2   Mutation details: The open reading frame of the gene was replaced with the Sox2 open reading frame. RT-PCR confirmed elevated expression of Sox2 in hemizygous embryos. (J:246645)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sox3 Mutation:	7 strains or lines available

Original:	J:246645 Adikusuma F, et al., Functional Equivalence of the SOX2 and SOX3 Transcription Factors in the Developing Mouse Brain and Testes. Genetics. 2017 Jul;206(3):1495-1503
All:	1 reference(s)