Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Slc5a5tm1c(KOMP)Wtsi
Name:	solute carrier family 5 (sodium iodide symporter), member 5; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID:	MGI:6111966
Gene:	Slc5a5  Location: Chr8:71335533-71345401 bp, - strand  Genetic Position: Chr8, 34.36 cM, cytoband C1
Alliance:	Slc5a5tm1c(KOMP)Wtsi page
IMPC:	Slc5a5 gene page

Germline Transmission:	Earliest citation of germline transmission: J:250121
Parent Cell Line:	JM8A3.N1 (ES Cell)
Strain of Origin:	C57BL/6N-Atm1Brd
Project Collection:	KOMP-CSD

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion   Mutation details: The L1L2_Bact_P cassette was inserted at position 71341753 of Chromosome 8 upstream of the critical exons 6 and 7 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exons 6 and 7 at position 71342751. The critical exons 6 and 7 are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression. (J:250121)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc5a5 Mutation:	37 strains or lines available

Original:	J:250121 Ferrandino G, et al., An extremely high dietary iodide supply forestalls severe hypothyroidism in Na+/I- symporter (NIS) knockout mice. Sci Rep. 2017 Jul 13;7(1):5329
All:	2 reference(s)