Nfe2l1tm1c(EUCOMM)Hmgu
Targeted Allele Detail
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| Symbol: |
Nfe2l1tm1c(EUCOMM)Hmgu |
| Name: |
nuclear factor, erythroid derived 2,-like 1; targeted mutation 1c, Helmholtz Zentrum Muenchen GmbH |
| MGI ID: |
MGI:6101514 |
| Synonyms: |
Nrf1flox |
| Gene: |
Nfe2l1 Location: Chr11:96708240-96720794 bp, - strand Genetic Position: Chr11, 60.12 cM, cytoband D-E
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| Alliance: |
Nfe2l1tm1c(EUCOMM)Hmgu page
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| IMPC: |
Nfe2l1 gene page |
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| Mutant Cell Line: |
HEPD0624_2_A05 |
| Germline Transmission: |
Earliest citation of germline transmission:
J:250015
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| Parent Cell Line: |
JM8A3.N1 (ES Cell)
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| Strain of Origin: |
C57BL/6N-Atm1Brd
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| Project Collection: |
EUCOMM
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| Allele Type: |
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Targeted (Conditional ready) |
| Mutation: |
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Insertion
Vector: L1L2_Bact_P
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Mutation details: The L1L2_Bact_P cassette was inserted at position 96707964 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 96711814. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:250015)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Nfe2l1 Mutation: |
39 strains or lines available
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| Original: |
J:250015 Widenmaier SB, et al., NRF1 Is an ER Membrane Sensor that Is Central to Cholesterol Homeostasis. Cell. 2017 Nov 16;171(5):1094-1109.e15 |
| All: |
3 reference(s) |
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Analysis Tools
