Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Esyt2tm1.3Sud
Name:	extended synaptotagmin-like protein 2; targeted mutation 1.3, Thomas C Sudhof
MGI ID:	MGI:6101172
Synonyms:	D4A
Gene:	Esyt2  Location: Chr12:116244816-116354670 bp, + strand  Genetic Position: Chr12, Syntenic
Alliance:	Esyt2tm1.3Sud page

Germline Transmission:	Earliest citation of germline transmission: J:236019
Parent Cell Line:	ART B6-3, B6-3 (ES Cell)
Strain of Origin:	C57BL/6NTac

Allele Type:    Targeted (Constitutively active) Mutations:    Insertion, Nucleotide substitutions   Mutation details: Flp-mediated excition of F3 sequences in Esyt2 resulted in the removal of the neomycin selection cassette and endogenous exon 10, leaving a mutant form (D4A) of exon 10. This allele expresses a constitutive mutant protein in which the four C2A-domain Ca(2+) binding sites of the C2A-domain are selectively abolished. (J:236019)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Esyt2 Mutation:	43 strains or lines available

Original:	J:236019 Sclip A, et al., Extended Synaptotagmin (ESyt) Triple Knock-Out Mice Are Viable and Fertile without Obvious Endoplasmic Reticulum Dysfunction. PLoS One. 2016;11(6):e0158295
All:	1 reference(s)