Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Relatm1.1Barts
Name:	v-rel reticuloendotheliosis viral oncogene homolog A (avian); targeted mutation 1.1, Bart van de sluis
MGI ID:	MGI:5908883
Synonyms:	p65S467A
Gene:	Rela  Location: Chr19:5687511-5698158 bp, + strand  Genetic Position: Chr19, 4.34 cM, cytoband B1-3
Alliance:	Relatm1.1Barts page

Germline Transmission:	Earliest citation of germline transmission: J:251115
Parent Cell Line:	TL1/TL-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Not Applicable) Mutation:    Single point mutation   Mutation details: The targeting vector is designed to insert a loxP-flanked neomycin (neo) resistance cassette downstream of exon 10 of the gene. A T to G transition was introduced in exon 11, corresponding to human amino acid 468, resulting in a mutation, S467A. Cre-mediated recombination removed the upstream floxed neo cassette. (J:251115)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rela Mutation:	24 strains or lines available

Original:	J:251115 Riedlinger T, et al., NF-kappaB p65 serine 467 phosphorylation sensitizes mice to weight gain and TNFalpha-or diet-induced inflammation. Biochim Biophys Acta. 2017 Oct;1864(10):1785-1798
All:	1 reference(s)