Sirt1tm1.1Arte
Targeted Allele Detail
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| Symbol: |
Sirt1tm1.1Arte |
| Name: |
sirtuin 1; targeted mutation 1.1, TaconicArtemis |
| MGI ID: |
MGI:5908448 |
| Synonyms: |
TAKI |
| Gene: |
Sirt1 Location: Chr10:63154784-63174814 bp, - strand Genetic Position: Chr10, 32.57 cM
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| Alliance: |
Sirt1tm1.1Arte page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:241351
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
C57BL/6NTac
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| Allele Type: |
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Targeted (Not Applicable) |
| Mutation: |
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Single point mutation
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Mutation details: An A>G point mutation was engineered to change codon 522 in exon 8 from threonine to alanine (p.Thre522Ala). Alanine is non-phosphorylatable, rendering the protein constitutively inactive. A loxP site and an FRT site flanked selectable marker cassette were inserted into intron 7. The marker cassette was removed through subsequent flp-mediated recombination.
(J:241351)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Sirt1 Mutation: |
78 strains or lines available
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| Original: |
J:241351 Lu J, et al., The phosphorylation status of T522 modulates tissue-specific functions of SIRT1 in energy metabolism in mice. EMBO Rep. 2017 May;18(5):841-857 |
| All: |
1 reference(s) |
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Analysis Tools
