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Gata4tm1.1(Gata6)Suss
Targeted Allele Detail
Summary
Symbol: Gata4tm1.1(Gata6)Suss
Name: GATA binding protein 4; targeted mutation 1.1, Lori Sussel
MGI ID: MGI:5907034
Synonyms: Gata4Gata6
Gene: Gata4  Location: Chr14:63436371-63509141 bp, - strand  Genetic Position: Chr14, 33.24 cM
Alliance: Gata4tm1.1(Gata6)Suss page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:229483
Parent Cell Line:  Other (see notes) (ES Cell)
Strain of Origin:  (C57BL/6J x 129S6/SvEvTac)F1
Mutation
description
Allele Type:    Targeted (Inserted expressed sequence, Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Gata4tm1.1(Gata6)Suss expresses 1 gene
 
Mutation details: A construct containing a 3X-myc tagged Gata6 short isoform cDNA, polyA sequence and FRT flanked neo cassette replaced exon 2 downstream of the start signal. Flp mediated recombination removed the neo cassette. Western blot analysis confirmed the expression of the myc-tagged GATA6. (J:229483)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gata4 Mutation:  36 strains or lines available
Notes
ES cell line = KV9, established from (C57BL/6J x 129S6/SvEvTac)F1 by Victor Lin, Columbia University.
References
Original:  J:229483 Borok MJ, et al., Unique functions of Gata4 in mouse liver induction and heart development. Dev Biol. 2016 Feb 15;410(2):213-22
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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04/16/2024
MGI 6.23 		The Jackson Laboratory