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Slc13a4tm1d(EUCOMM)Wtsi
Targeted Allele Detail
Nomenclature
Symbol: Slc13a4tm1d(EUCOMM)Wtsi
Name: solute carrier family 13 (sodium/sulfate symporters), member 4; targeted mutation 1d, Wellcome Trust Sanger Institute
MGI ID: MGI:5881938
Synonyms: Slc13a4-
Gene: Slc13a4  Location: Chr6:35267953-35308126 bp, - strand  Genetic Position: Chr6, 15.26 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:239786
Parent Cell Line:  JM8.N4 (ES Cell)
Strain of Origin:  C57BL/6N
Project Collection: EUCOMM
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe L1L2_Bact_P cassette was inserted at position 35290377 of Chromosome 6 upstream of the critical exon(s) (Build GRCm38). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon(s) at position 35289566. The critical exon(s) is/are thus flanked by loxP sites. A null/knockout allele was created by flp and cre recombinase expression in mice carrying this allele to remove the lacZ sequence, neo selection cassette and the loxP-flanked critical exon(s). (J:239786)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc13a4 Mutation:  18 strains or lines available
References
Original:  J:239786 Rakoczy J, et al., Loss of the sulfate transporter Slc13a4 in placenta causes severe fetal abnormalities and death in mice. Cell Res. 2015 Nov;25(11):1273-6
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/19/2020
MGI 6.15
The Jackson Laboratory