Brca1tm2Jjon
Targeted Allele Detail
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| Symbol: |
Brca1tm2Jjon |
| Name: |
breast cancer 1, early onset; targeted mutation 1, Jos Jonkers |
| MGI ID: |
MGI:5823771 |
| Synonyms: |
Brca1185stop |
| Gene: |
Brca1 Location: Chr11:101379590-101442781 bp, - strand Genetic Position: Chr11, 65.18 cM, cytoband D
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| Alliance: |
Brca1tm2Jjon page
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| Germline Transmission: |
Earliest citation of germline transmission:
J:237116
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| Parent Cell Line: |
Not Specified (ES Cell)
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| Strain of Origin: |
Not Specified
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| Allele Type: |
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Targeted (Null/knockout) |
| Mutation: |
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Nucleotide substitutions
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Mutation details: Nonchemically modified deoxyribonucleotides were used to introduce the (5-ATGCAGAAAATCTTAGAGTAGGCGATCTGGTAAGTCAACA-3) mutation into a mouse ES cell line. This alteration is a substitution of 3 nucleotides (TCC to AAG) at position 185, resulting in an early STOP codon at aa 24 of the encoded protein.
(J:237116)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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| Carrying any Brca1 Mutation: |
113 strains or lines available
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| Original: |
J:237116 Drost R, et al., BRCA1185delAG tumors may acquire therapy resistance through expression of RING-less BRCA1. J Clin Invest. 2016 Aug 01;126(8):2903-18 |
| All: |
1 reference(s) |
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Analysis Tools
