Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Sgpp2tm1Rlp Name: sphingosine-1-phosphate phosphatase 2; targeted mutation 1, Richard L Proia MGI ID: MGI:5823275 Synonyms: Sgpp2- Gene: Sgpp2  Location: Chr1:78286982-78396926 bp, + strand  Genetic Position: Chr1, 40.23 cM Alliance: Sgpp2tm1Rlp page

Sgpp2tm1Rlp/Sgpp2tm1Rlp mice showed normal skin appearance similar to wild-type mice, in contrast to severe ichtyosis in Sgpp1tm1(KOMP)Vlcg/Sgpp1tm1(KOMP)Vlcg mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:235035
Parent Cell Line:	TC1/TC-1 (ES Cell)
Strain of Origin:	129S6/SvEvTac

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a genomic fragment containing exons 3 and 4. Various tissues of homozygous mice failed to express detectable transcripts, as detected by semiquantitative real-time PCR. Total sphingosine-1-phosphate phosphatase (SPPase) enzymatic activity was decreased by ~30% in the membrane fraction from homozygous mutant lung tissue. (J:235035)

Generation of the Sgpp2tm1Rlp allele

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sgpp2 Mutation:	14 strains or lines available

Original:	J:235035 Taguchi Y, et al., Sphingosine-1-phosphate Phosphatase 2 Regulates Pancreatic Islet beta-Cell Endoplasmic Reticulum Stress and Proliferation. J Biol Chem. 2016 Jun 3;291(23):12029-38
All:	1 reference(s)