Tcf7tm1c(EUCOMM)Wtsi
Targeted Allele Detail
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Symbol: |
Tcf7tm1c(EUCOMM)Wtsi |
Name: |
transcription factor 7, T cell specific; targeted mutation 1c, Wellcome Trust Sanger Institute |
MGI ID: |
MGI:5816259 |
Synonyms: |
Tcf7FL, Tcf7loxP |
Gene: |
Tcf7 Location: Chr11:52143198-52174158 bp, - strand Genetic Position: Chr11, 31.86 cM
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Alliance: |
Tcf7tm1c(EUCOMM)Wtsi page
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IMPC: |
Tcf7 gene page |
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Mutant Cell Line: |
EPD0023_2_A12 |
Germline Transmission: |
Earliest citation of germline transmission:
J:236661
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Parent Cell Line: |
C2 (Nagy) (ES Cell)
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Strain of Origin: |
C57BL/6NTac
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Project Collection: |
EUCOMM
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Allele Type: |
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Targeted (Conditional ready) |
Mutation: |
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Insertion
Vector: L1L2_gt0
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Mutation details: The L1L2_gt0 cassette was inserted at position 52151908 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 52153021. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s).
(J:236661)
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Original: |
J:236661 Wu T, et al., TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Rep. 2015 Sep 29;12(12):2099-110 |
All: |
26 reference(s) |
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