Summary | Mutation origin | Mutation description | Expression | Find Mice (IMSR) | References

Symbol:	Tcf7tm1c(EUCOMM)Wtsi
Name:	transcription factor 7, T cell specific; targeted mutation 1c, Wellcome Trust Sanger Institute
MGI ID:	MGI:5816259
Synonyms:	Tcf7FL, Tcf7loxP
Gene:	Tcf7  Location: Chr11:52143198-52174158 bp, - strand  Genetic Position: Chr11, 31.86 cM
Alliance:	Tcf7tm1c(EUCOMM)Wtsi page
IMPC:	Tcf7 gene page

Mutant Cell Line:	EPD0023_2_A12
Germline Transmission:	Earliest citation of germline transmission: J:236661
Parent Cell Line:	C2 (Nagy) (ES Cell)
Strain of Origin:	C57BL/6NTac
Project Collection:	EUCOMM

Allele Type:    Targeted (Conditional ready) Mutation:    Insertion     Vector: L1L2_gt0   Mutation details: The L1L2_gt0 cassette was inserted at position 52151908 of Chromosome 11 upstream of the critical exon(s) (Build GRCm39). The cassette is composed of an FRT flanked lacZ/neomycin sequence followed by a loxP site. An additional loxP site is inserted downstream of the targeted exon(s) at position 52153021. The critical exon(s) is/are thus flanked by loxP sites. A "conditional ready" (floxed) allele was created by flp recombinase expression in mice carrying this allele to remove the lacZ sequence and neo selection cassette, leaving loxP sites flanking the critical exon(s). (J:236661)

In Mice Carrying this Mutation:

1 RNA-Seq or microarray experiment(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Tcf7 Mutation:	24 strains or lines available

Original:	J:236661 Wu T, et al., TCF1 Is Required for the T Follicular Helper Cell Response to Viral Infection. Cell Rep. 2015 Sep 29;12(12):2099-110
All:	26 reference(s)