Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Tumor data | Find Mice (IMSR) | References

Symbol:	Axltm1Grl
Name:	AXL receptor tyrosine kinase; targeted mutation 1, Greg Lemke
MGI ID:	MGI:2387750
Synonyms:	Axl-
Gene:	Axl  Location: Chr7:25456698-25488130 bp, - strand  Genetic Position: Chr7, 14.02 cM, cytoband A3-B1
Alliance:	Axltm1Grl page

Germline Transmission:	Earliest citation of germline transmission: J:54681
Parent Cell Line:	CB1-4 (ES Cell)
Strain of Origin:	C57BL/6J x (Rb(11.16)2H x Rb(16.17)32Lub)F1

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A neomycin selection cassette replaced a segment of the gene containing exon 9. Western blot analysis on total brain lysates derived from homozygous mice demonstrated that no detectable protein was produced from this allele. (J:54681)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

List all tumor models in MMHCdb carrying Axltm1Grl

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Axl Mutation:	58 strains or lines available

Original:	J:54681 Lu Q, et al., Tyro-3 family receptors are essential regulators of mammalian spermatogenesis. Nature. 1999 Apr 22;398(6729):723-8
All:	75 reference(s)