Tg(Acta2-AKR1B1)#Pfk
Transgene Detail
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| Symbol: |
Tg(Acta2-AKR1B1)#Pfk |
| Name: |
transgene insertion, Peter Kador |
| MGI ID: |
MGI:5805235 |
| Synonyms: |
SMAA-hAR |
| Transgene: |
Tg(Acta2-AKR1B1)#Pfk Location: unknown
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| Alliance: |
Tg(Acta2-AKR1B1)#Pfk page
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| Transgene Type: |
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Transgenic (Inserted expressed sequence, Reporter) |
| Mutation: |
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Insertion
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Tg(Acta2-AKR1B1)#Pfk expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
AKR1B1 (231) |
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Mutation details: The transgene contains the promoter region of the mouse actin, alpha 2, smooth muscle, aorta (Acta2) gene, including 1074 bp of 5' flanking region, the transcription start site, the 48-bp first exon, the ~2.5-kb first intron, and 15 bp of exon 2, driving expression of human aldo-keto reductase family 1, member B (also called aldose reductase). Transgenic mice express AKR1B1 specifically in both vascular and nonvascular smooth muscle cells and also in the cone bipolar cells of the retina.
(J:43053, J:195671)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:195671 Kador PF, et al., Novel diabetic mouse models as tools for investigating diabetic retinopathy. PLoS One. 2012;7(12):e49422 |
| All: |
3 reference(s) |
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Analysis Tools
