Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Irf4M2Btlr
Name:	interferon regulatory factor 4; mutation 2, Bruce Beutler
MGI ID:	MGI:5789556
Synonyms:	Honey2
Gene:	Irf4  Location: Chr13:30933209-30950959 bp, + strand  Genetic Position: Chr13, 13.28 cM, cytoband A3.3
Alliance:	Irf4M2Btlr page

Strain of Origin:	C57BL/6J
Project Collection:	Beutler Mutagenetix

Allele Type:    Chemically induced (ENU) (Not Specified) Mutation:    Single point mutation   Mutation details: ENU-induced T to C transition at base pair 30,761,490 (v38) on chromosome 13, or base pair 12,283 in the GenBank genomic region NC_000079 within the donor splice site of intron 8. The effect of the mutation at the cDNA and protein level has not examined. The mutation is judged unlikely to disrupt the splice donor site of intron 8 by splice prediction programs. In the case that this mutation affects splicing, a cryptic splice site in exon 8 might be used, resulting in a transcript that has a 50 base-pair deletion in exon 8 (out of 9 total exons). The mutation would lead to a frame-shifted protein product beginning after amino acid 388 of the protein, followed by premature termination after the inclusion of 26 aberrant amino acids. (J:234245) Inheritance:    Semidominant

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Irf4 Mutation:	27 strains or lines available

Original:	J:234245 Choi JH, et al., Mutagenetix entry for Honey2. MGI Direct Data Submission. 2016;
All:	1 reference(s)